On 22 October 2019, the Luxembourg Space Agency and NASA, the US federal space  agency, signed a joint statement of intent to further deepen US-Luxembourg cooperation in space. The agreement was signed during the 70th International Astronautical Congress held in Washington DC on 21-25 October. This agreement is a continuation of the Memorandum of Understanding (MoU) on space between the US and Luxembourg governments, signed in May this year. The MoU designated NASA and LSA to exchange information about prospective collaboration.

LSA also signed a second collaboration agreement during the International Astronautical Congress, this time with the German Aerospace Centre (DLR). Through a Letter of Intent, the two agencies agreed to work together in the field of space research activities. The cooperation will in particular focus on topics such as navigation, satellite communications, space exploration and space resources, including robotics and in-orbit services. The intention is to channel the collaboration through the interdisciplinary space resources research centre to be set up in Luxembourg as part of the SpaceResources.lu initiative.